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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from various geographical areas. This type of heterogeneity is necessary for practical trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.
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Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers in order to inform their decisions. They can also be a great method of determining the causality between the intervention and its effects. They should not, however be used to replace the need for explanation studies.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, 프라그마틱 정품 which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a practical trial that include the recruitment process, the design and delivery of the intervention, and the follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.