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Pragmatic trials are trials designed to provide information for real-world clinical practice. They are often described as a focus on the practical aspects of study design which include recruitment and consent, adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This type of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. A high degree of heterogeneity, however can result in problems with the design of the trial.

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Legality

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. Usually, they are commissioned by policymakers and practitioners to guide their decisions. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. They should not, however, be used to replace explanation studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a practical study that includes the recruitment, design, and delivery of the intervention, and follow-up.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and 프라그마틱 이미지 naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.